†Please see Patient Information. Follow appropriate administration steps in the Instructions for Use. Monitor for signs and symptoms of an allergic reaction for at least 30 minutes after injection. If an allergic reaction occurs, you should seek medical attention.
Personalized one-on-one training
You can self-inject, or a caregiver can do it for you. You can still get your injection from a healthcare professional.
You and/or your caregiver will receive in-person training at home or in your doctor’s office until you’re ready to inject on your own. You’ll also get a demonstration kit to help you practice.
Considerations when choosing a CIDP treatment
As you prep for your next doctor’s visit, use this chart to help learn about the different ways CIDP treatments can be given. This is an educational tool, not a comparison of effectiveness or safety for these treatments.
The information listed for each treatment refers to an individual dose.
| VYVGART Hytrulo prefilled syringe | Injection |
|---|---|
| VYVGART Hytrulo viala | Injection |
| IVIg | Infusion |
| SCIg | Infusion |
a Comes in a vial and is given by a healthcare professional using a winged infusion set.
IV=intravenous; IVIg=intravenous immunoglobulin; SC=subcutaneous; SCIg=subcutaneous immunoglobulin.
| VYVGART Hytrulo prefilled syringe | About |
|---|---|
| VYVGART Hytrulo viala | About |
| IVIg | About |
| SCIg | Up to |
a Comes in a vial and is given by a healthcare professional using a winged infusion set.
b Does not include preparation or monitoring time.
IV=intravenous; IVIg=intravenous immunoglobulin; SC=subcutaneous; SCIg=subcutaneous immunoglobulin.
| VYVGART Hytrulo prefilled syringe | Yesc |
|---|---|
| VYVGART Hytrulo viala | No |
| IVIg | No |
| SCIg | Yesc |
a Comes in a vial and is given by a healthcare professional using a winged infusion set.
c Training required from a healthcare professional.
IV=intravenous; IVIg=intravenous immunoglobulin; SCIg=subcutaneous immunoglobulin.
| VYVGART Hytrulo prefilled syringe | 1 |
|---|---|
| VYVGART Hytrulo viala | 1 |
| IVIg | 1 |
| SCIg | 1-8 |
a Comes in a vial and is given by a healthcare professional using a winged infusion set.
IV=intravenous; IVIg=intravenous immunoglobulin; SC=subcutaneous; SCIg=subcutaneous immunoglobulin.
| VYVGART Hytrulo prefilled syringe | Once weekly |
|---|---|
| VYVGART Hytrulo viala | Once weekly |
| IVIg | About once every 3‑6 weeks |
| SCIg | Treatments can be once weekly or once every 1‑4 weeks |
a Comes in a vial and is given by a healthcare professional using a winged infusion set.
IV=intravenous; IVIg=intravenous immunoglobulin; SC=subcutaneous; SCIg=subcutaneous immunoglobulin.
| VYVGART Hytrulo prefilled syringe | VYVGART Hytrulo viala | IVIg | SCIg | |
|---|---|---|---|---|
 How is it given? | Injection | Injection | Infusion | Infusion |
 How long | About | About | About | Up to |
 Can I do it myself? | Yesc | No | No | Yesc |
 How many injection or infusion sites are involved? | 1 | 1 | 1 | 1-8 |
 How frequently is it given? | Once | Once | About once every | Treatments can be once weekly or once every 1‑4 weeks |
a Comes in a vial and is given by a healthcare professional using a winged infusion set.
b Does not include preparation or monitoring time.
c Training required from a healthcare professional.
IV=intravenous; IVIg=intravenous immunoglobulin; SC=subcutaneous; SCIg=subcutaneous immunoglobulin.
Learn more about VYVGART Hytrulo
VYVGART Hytrulo study results
See the safety and effectiveness results from the largest clinical study in CIDP history.
Cost and coverage
Find resources and information that may help you navigate your VYVGART Hytrulo treatment for CIDP.
Do not take VYVGART HYTRULO if you are allergic to efgartigimod alfa, hyaluronidase, or any of the ingredients in VYVGART HYTRULO. VYVGART HYTRULO can cause serious allergic reactions and a decrease in blood pressure leading to fainting.
Before taking VYVGART HYTRULO, tell your healthcare provider about all of your medical conditions, including if you:
- have an infection or fever.
- have recently received or are scheduled to receive any vaccinations.
- have any history of allergic reactions.
- have kidney (renal) problems.
- are pregnant or plan to become pregnant. It is not known whether VYVGART HYTRULO will harm your unborn baby.
- Pregnancy Exposure Registry. There is a pregnancy exposure registry for women who use VYVGART HYTRULO during pregnancy. The purpose of this registry is to collect information about your health and your baby. Your healthcare provider can enroll you in this registry. You may also enroll yourself or get more information about the registry by calling 1-855-272-6524 or going to VYVGARTPregnancy.com
- are breastfeeding or plan to breastfeed. It is not known if VYVGART HYTRULO passes into your breast milk.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
VYVGART HYTRULO can cause side effects which can be serious, including:
- Infection. VYVGART HYTRULO may increase the risk of infection. If you have an active infection, your healthcare provider should delay your treatment with VYVGART HYTRULO until your infection is gone. Tell your healthcare provider right away if you get any of the following signs and symptoms of an infection:
- fever
- chills
- frequent and painful urination
- cough
- pain and blockage of nasal passages
- wheezing
- shortness of breath
- sore throat
- excess phlegm
- nasal discharge
- Allergic reactions (hypersensitivity reactions). VYVGART HYTRULO can cause allergic reactions that can be severe. These reactions can happen during, shortly after, or weeks after your VYVGART HYTRULO injection. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
- rash
- swelling of the face, lips, throat, or tongue
- shortness of breath
- hives
- trouble breathing
- low blood pressure
- fainting
- Infusion or injection-related reactions. VYVGART HYTRULO can cause infusion or injection-related reactions. These reactions can happen during or shortly after your VYVGART HYTRULO injection. Tell your healthcare provider if you have any of the following symptoms of an infusion or injection-related reaction:
- high blood pressure
- chills
- shivering
- chest, stomach, or back pain
The most common side effects of VYVGART HYTRULO include respiratory tract infection, headache, urinary tract infection, and injection site reactions.
These are not all the possible side effects of VYVGART HYTRULO. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is VYVGART HYTRULO® (efgartigimod alfa and hyaluronidase-qvfc)?
VYVGART HYTRULO is a prescription medicine used to treat adults with chronic inflammatory demyelinating polyneuropathy (CIDP).
It is not known if VYVGART HYTRULO is safe and effective in children.
Please see full Prescribing and Patient Information for VYVGART HYTRULO.
Dosage forms and strengths:
VYVGART Hytrulo is available as a single-dose subcutaneous injection containing: 200 mg/mL of efgartigimod alfa and 2,000 U/mL of hyaluronidase per prefilled syringe, or 180 mg/mL of efgartigimod alfa and 2,000 U/mL of hyaluronidase per vial.
IMPORTANT SAFETY INFORMATION
Do not take VYVGART HYTRULO if you are allergic to efgartigimod alfa, hyaluronidase, or any of the ingredients in VYVGART HYTRULO. VYVGART HYTRULO can cause serious allergic reactions and a decrease in blood pressure leading to fainting.
Before taking VYVGART HYTRULO, tell your healthcare provider about all of your medical conditions, including if you:
- have an infection or fever.
- have recently received or are scheduled to receive any vaccinations.
- have any history of allergic reactions.
- have kidney (renal) problems.
- are pregnant or plan to become pregnant. It is not known whether VYVGART HYTRULO will harm your unborn baby.
- Pregnancy Exposure Registry. There is a pregnancy exposure registry for women who use VYVGART HYTRULO during pregnancy. The purpose of this registry is to collect information about your health and your baby. Your healthcare provider can enroll you in this registry. You may also enroll yourself or get more information about the registry by calling 1-855-272-6524 or going to VYVGARTPregnancy.com
- are breastfeeding or plan to breastfeed. It is not known if VYVGART HYTRULO passes into your breast milk.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
VYVGART HYTRULO can cause side effects which can be serious, including:
- Infection. VYVGART HYTRULO may increase the risk of infection. If you have an active infection, your healthcare provider should delay your treatment with VYVGART HYTRULO until your infection is gone. Tell your healthcare provider right away if you get any of the following signs and symptoms of an infection:
- fever
- chills
- frequent and painful urination
- cough
- pain and blockage of nasal passages
- wheezing
- shortness of breath
- sore throat
- excess phlegm
- nasal discharge
- Allergic reactions (hypersensitivity reactions). VYVGART HYTRULO can cause allergic reactions that can be severe. These reactions can happen during, shortly after, or weeks after your VYVGART HYTRULO injection. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
- rash
- swelling of the face, lips, throat, or tongue
- shortness of breath
- hives
- trouble breathing
- low blood pressure
- fainting
- Infusion or injection-related reactions. VYVGART HYTRULO can cause infusion or injection-related reactions. These reactions can happen during or shortly after your VYVGART HYTRULO injection. Tell your healthcare provider if you have any of the following symptoms of an infusion or injection-related reaction:
- high blood pressure
- chills
- shivering
- chest, stomach, or back pain
The most common side effects of VYVGART HYTRULO include respiratory tract infection, headache, urinary tract infection, and injection site reactions.
These are not all the possible side effects of VYVGART HYTRULO. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is VYVGART HYTRULO® (efgartigimod alfa and hyaluronidase-qvfc)?
VYVGART HYTRULO is a prescription medicine used to treat adults with chronic inflammatory demyelinating polyneuropathy (CIDP).
It is not known if VYVGART HYTRULO is safe and effective in children.
Please see full Prescribing and Patient Information for VYVGART HYTRULO.
Dosage forms and strengths:
VYVGART Hytrulo is available as a single-dose subcutaneous injection containing: 200 mg/mL of efgartigimod alfa and 2,000 U/mL of hyaluronidase per prefilled syringe, or 180 mg/mL of efgartigimod alfa and 2,000 U/mL of hyaluronidase per vial.
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